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Many patients require transfer from a local hospital which delays treatment

[5] [6] Early-phase clinical trials including a Phase 2 trial published in the New England Journal of Medicine (2023) have reported significant reductions in body weight and improvements in metabolic markers, though this evidence remains preliminary and is not sufficient to establish a clinical dosing or reconstitution standard

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The DIRD is required to review, monitor and report on the DDA acquittals and conduct project inspections to verify the expenditure.10 The DIRD has a Monitoring Unit, with regional offices, to conduct physical inspections and verification of projects funded through the DSIP

In Parkinsons disease, patients complain of gastrointestinal symptoms years prior to diagnosis [95, 109]