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Potential CNS Access : Some research suggests nasal administration may facilitate direct transport to the central nervous system via olfactory and trigeminal nerve pathways, though this remains an area of ongoing investigation [5]

We were also interested in whether the D2R-DAT disruption can strengthen dopamine signaling even under hypo-dopaminergic signaling

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The oxygen is then deprotonated (Step 3, arrows E and F)

Despite the extensive and multidisciplinary research during recent years, and the growing evidence on the anatomical and physiological lines of mucosal defense, the functional aspects of protection and healing still need to be better understood