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When the calcium binds to a protein called synaptotagmin, on the vesicles' surfaces, synaptotagmin teams up with other proteins to tug some of the vesicles, winch-style, closer and closer to the neuron's surface membrane until their enclosing membranes fuse with it, spilling the vesicles' contents into the surrounding environment

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The integrated relaxation pressure (IRP), which is a marker of deglutitive LES relaxation, is the lowest mean LES pressure for 4 noncontiguous seconds in the first 10 seconds after a swallow

These preventive measures reduce the risk of telogen effluvium and keep hair health intact