Reduced active transcellular intestinal oxalate secretion contributes to the pathogenesis of obesity-associated hyperoxaluria
Furthermore, GIP inhibits hindbrain neurons regulating emesis [25] and GIP agonism reduces emesis caused by a GLP-1 RA in both rodent and human studies [25, 26]
status epilepticus may indicate either continued absorption from cocaine-filled condoms in the GI tract or the presence of significant hyperthermia) Coma can be caused by seizures (postictal state), hyperthermia or an intracranial hemorrhage caused by cocaine-induced hypertension Cardiovascular : Chest pain MI, arrhythmias & prolonged QTc Tachycardia Hypertension Cardiomyopathy (chronic use) Other : Hyperthermia Dilated pupils (mydriasis) Insomnia, weight loss (with chronic use) : Sudden Death Cocaine abuse is associated with an increased incidence of sudden death from multiple mechanisms Most acute cocaine-related nontraumatic deaths are believed to result from tachyarrhythmias Other causes of sudden death associated with cocaine use include stroke, subarachnoid hemorrhage, hyperthermia, and the consequences of agitated delirium Myocardial infarction can result from acute vasospasm, dysrhythmias, or chronic accelerated atherogenic disease Treatment: Establish ABC's Provide oxygen, i.v
Until recently intravenous delivery of glutathione has proven to be the most effective route for absorption, but this method is both costly and impractical
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