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It phosphorylates upstream stimulatory factor 1 (USF1) and then upregulate fatty acid synthase (FASN), which promotes de novo lipogenesis (DNL) in liver and aggravates hepatic fat deposition

Notably, zein-based nanocapsules demonstrated 3.3-fold greater oxidative stability compared to kafirin-based nanocapsules, a difference that aligns with their higher oil encapsulation efficiency (99)

Clinical observations have noted improvements in the appearance of fine lines, coarse wrinkles, and skin density with consistent topical use

In the Phase 2 trial, 72% of participants who had prediabetes at the start had normal glycated hemoglobin levels at 48 weeks, compared to just 22% on placebo

10.1080/09513590.2019.1650345 Gynecol